Translational Mini-Review Series on Toll-like Receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity
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منابع مشابه
Toll-like Receptors and Innate Immunity
Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogenand modified selfderived molecules, TLRs trigger intracellular signaling cascades that involve various adaptor proteins and enzymes, resulting in the generation of proinflammatory and antim...
متن کاملToll-like receptors in innate immunity.
Functional characterization of Toll-like receptors (TLRs) has established that innate immunity is a skillful system that detects invasion of microbial pathogens. Recognition of microbial components by TLRs initiates signal transduction pathways, which triggers expression of genes. These gene products control innate immune responses and further instruct development of antigen-specific acquired i...
متن کاملI-23: Reproduction and Toll Like Receptors(TLRs
Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...
متن کاملToll-like receptors, innate immunity and lung transplantation.
Lung transplant allografts have the highest rate of rejection and shortest graft survival time among the commonly transplanted solid organs despite high levels of immunosuppression. This observation strongly indicates that mechanisms unique to the lung allograft contribute to rejection post lung transplant. Unlike most other solid organ recipients, the lung allograft is exposed to both the exte...
متن کاملThe Role of Toll-Like Receptors in Breast Cancer
Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2007
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2006.03203.x